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Ketones: Miracle or myth?

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Peter Stuart
3 May 2019

As a scientist credits Deceuninck-Quick Step’s success to ketones, we look at whether the supplement’s gains are fact or fiction

Ketones have been lauded as the new secret weapon in pro cycling, with rumours circulating for years of top teams using ketones in races at a cost of thousands per bottle. With the supplement coming into the mainstream and down in price, though, some now consider it a key necessity for high-end competition.

Dutch website Sporza reported today that an advisor for Deceuninck-Quick Step, Professor Peter Hespel, has claimed that ketones were ‘a piece of the puzzle’ in Quick-Steps fantastic success last year.

He went on to claim, ‘I think there are very few endurance athletes who don't know that something is happening with ketones and are already experimenting.’

This is not the first insider from the sport to discuss ketones, as ex-Team Sky member Greg Henderson discussed their suspected use in the team.  He subsequently trialled the supplement and claimed enormous physiological gains. 

While it would seem that ketones are becoming an open secret in pro cycling, and necessary to compete at elite level, first we need to clarify exactly what they are.

What are Ketones? 

‘A ketone is another energy source,’ explains Kieran Clarke, Professor of Physiological Biochemistry at Oxford University, and inventor of the first ketone-based drink DeltaG. 

A ketone is normally metabolized by the body to create energy, and originates from fats. ‘It's produced normally when you haven’t eaten or when you're on a kesogenic diet,’ Clarke explains.

‘The research was originally funded by the research arm of the US army,’ she says. ‘They wanted somebody to invent a really efficient food and we said we could do that.’

The drink created by Clarke means that you can put ketones straight into your body that can be turned into energy. ‘It has similar effects to glucose and it works in the same way as glucose drinks, it provides energy for your muscles.’

Crucially, though, it has no discernable advantages over glucose. The main advantage, Clarke argues, is topping up your energy as your glycogen levels become depleted. ‘Things that last 5 or 6 hours it will probably be the best use for it. But I think it depends on the individual, and it also depends how efficient they are at using their various substrates.’

Marginal or massive gains?

Their inventor, Professor Kieran Clarke, sees no real advantages for the average athlete over glucose supplements and drinks. 

‘If you have glucose by itself or ketones by itself, it’s not superior. It’s exactly the same – it’s just providing energy. For sprints glucose is better actually, because you need something that’s anaerobic,’ she says. 

In response to rumours that athletes enjoy a 10% instant advantage at threshold pace when drinking a ketone ester, Clarke responds with restrained laughter: ‘No, I don’t think so! I think anyone who thinks that is having themselves on.’

However, ignoring claims of immediate threshold gains, the supplementation of ketones for an athlete with low fat and who has maxed out on carbohydrate and glucose intake in a race could be significant.

‘Once your glycogen is depleted you can't do anything about it,’ explains Clarke. ‘Your constantly topping up on glycogen when you're exercising. What they do mostly in the Tour de France is burning mainly fat, and glucose which they take in from drinks and gels.’

Eating enough to keep fat and carbohydrates in reserve is a better option in pure psychological terms, but the demands of racing mean that eating enough during competition isn’t always possible, or efficient. 

It seems that if any pro teams are using ketone supplements, then, the gains are likely to be noticeable improvements in energy over longer stages, which in turn extends to speeding up the recovery.

Will ketone supplements become standard amongst amateurs too, then?

Amateur hour

With the interaction of glucose, carbohydrates and ketones in mind, the use of ketones will only offer an advantage if an athletes glucose and carbohydrate strategy is already perfected, which is a downside for those of us dying between food stops on a sportive.

For amateur enthusiasts, it’s also worth being extremely diligent about which ketones we buy. Raspberry ketones, for instance, are cheap and widely available but have a big downside. 

‘Raspberry ketones which are not metabolised by the body,’ explains Clarke. Because they come from raspberries, they are only useful if you happen to be a raspberry.


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